• Barts

    Orthopaedics

    Research

    Next generation bone and joint research

  • About Us

    Research driven by innovation

    Who are we?

    Barts Orthopaedics Research is a unique team formed of creative and open minded clinicians. Over the last 3 years, our involvement in international and national trials has grown and the team are continuously working on developing homegrown projects. Innovation in healthcare research is at our core and we welcome collaboration with academics and industry, from bright new start-ups through to corporate leaders.

    Barts Orthopaedics

    The Barts Orthopaedics team are highly specialised in both adult and paediatric orthopaedic health - from routine joint replacement surgery through to limb reconstruction, complex pelvic and spinal surgery and highly specialised paediatric bone and joint surgery. The Royal London Hospital is also a Major Trauma Centre which is internationally recognised as a specialist centre for caring for seriously injured adults and children across London and the South East of England. Our other hospitals are Newham (to include the Gateway Barts Health Orthopaedic Centre) and Whipps Cross. Together we cover a local population of 2.5 million patients, making us the largest orthopaedic organisation in Europe.

    Work with us

    If you have an idea you would like to share, work with us or find out more please contact us.

  • Current Research

    International, national and homegrown research projects currently recruiting participants at Barts Health

    Bespoke

    Working with London's cyclists to make our roads safer

    Study initiated and developed by the team at Barts Orthopaedics, working to build a better environment for cyclists in London.

    Report cycling incidents or near misses at collideoscope.org.uk

    Latella-2

    Evaluation of the Latella Knee Implant System for Medial Osteoarthritis Pain Reduction

    International study initiated and developed by the team at Barts Orthopaedics following on from our successful first-in-man trial.

    Testing of a novel implant for the management of osteoarthritis

    WOLLF

    Wound management of Open Lower Limb Fractures

    A trial developed at The University of Warwick Clinical Trials Unit to compare infection rates with standard dressings or negative pressure wound therapy

    SWIFFT

    Scaphoid Waist Internal Fixation for Fractures Trial

    A trial developed at The University Leicester with York Clinical Trials Unit to compare surgical fixation with conservative management for scaphoid fractures

    TRIO-Physio

    Targeted physiotherapy to improve outcomes after TKR

    A trial developed at The University of Edinburgh Clinical Trials Unit to investigate the effect of targetted physiotherapy for patients with an Oxford Knee Score of 26 or below at their six week post-operative appointment

    NMES for Pelvic Fractures

    NMES (neuromuscular electrical muscle stimulation) and pelvic fracture rehabilitation

    Study initiated and developed by the team at Barts Orthopaedics to test the effect of NMES on patient rehabilitation following surgery to fix a fractured pelvis

    GUST

    Genetic markers of slipped capital femoral epiphysis: a pilot study

    A pilot study initiated and developed by Barts Orthopaedics and Queen Mary University London to analyse genetics of SCFE patients of all ages

    Health

    RCT comparing total hip arthroplasty and hemi-arthroplasty

    Coming soon...

    PATH-2

    RCT comparing PRP with placebo injection in adults with Achilles tendon rupture

    Coming soon...

  • Research Strands

    Our colleagues, collaborators and corporate partners

    Institute of Bioengineering at QMUL

    Manoj Ramachandran is Director of Clinical Strategy and Musculoskeletal Translational Research at the Institute of Bioengineering, School of Engineering & Materials Sciences, QMUL

    Manoj provides clinical leadership, innovation experience, and a critical patient-leading perspective. His work focuses on developing strategies for musculoskeletal regeneration, medical devices, and digital medicine. Current grants include sources such as MRC and ARUK.

    Cartilage and Bone Research

    Collaboration with the William Harvey Research Institute, QMUL

    We work with leading bone and cartilage scientists to explore the basic sciences of these tissues and to develop an Orthopaedic and Rheumatology Biobank (ORB) for strategies in stratified medicine. Current grants such as ARUK and NIHR.

    Mobile Health

    Developing apps that change healthcare

    Recent projects have included novel ways of consenting patients to collect medical images for teaching, research and clinical purposes and developing apps for tracking symptoms and providing rehabilitation in orthopaedic surgery. We have worked successfully with cutting edge start-ups such as umotif and with in-house embedded app developers such as QApps.

    Medical Devices

    Working with med tech companies in patient-focussed innovation

    We work closely with bright start-ups to deliver innovative med tech solutions for real-world clinical problems. Companies we work with or have worked with range from early stage start-ups, such as Cotera Inc and Andiamo, to those we have helped and supported through to exit, such as Pivot Medical Inc. We span the entire range of biodesign from ideation through prototyping and first-in-man studies to large scale multicentre trials.

  • Publications

    Recent publications from the Barts Orthopaedics Team (since 2013)

    Manoj Ramachandran

    Consultant Orthopaedic Surgeon & Director of Research

    Lead for Paediatric and Young Adult Orthopaedic Surgery

    C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT. Biochem Biophys Res Commun. 2015 Oct 2;465(4):784-9.

    doi: 10.1016/j.bbrc.2015.08.087. Epub 2015 Aug 22.

     

    Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M, Dell'Accio F. Ann Rheum Dis. 2015 Aug 19. pii: annrheumdis-2015-207316. doi: 10.1136/annrheumdis-2015-207316. [Epub ahead of print]


    Normal lower limb variants in children. Yeo A, James K, Ramachandran M. BMJ. 2015 Jul 7;350:h3394. doi: 10.1136/bmj.h3394.

     

    The inadequacy of musculoskeletal knowledge in graduating medical students in the United Kingdom. Al-Nammari SS, Pengas I, Asopa V, Jawad A, Rafferty M, Ramachandran M. J Bone Joint Surg Am. 2015 Apr 1;97(7):e36.

    doi: 10.2106/JBJS.N.00488.

     

    Pycnodysostosis and the making of an artist. Hodder A, Huntley C, Aronson JK, Ramachandran M.Gene. 2015 Jan 15;555(1):59-62. doi: 10.1016/j.gene.2014.09.055. Epub 2014 Sep 30.

     

    Clinical and historical aspects of the Elephant Man: exploring the facts and the myths.

    Huntley C, Hodder A, Ramachandran M. Gene. 2015 Jan 15;555(1):63-5.

    doi: 10.1016/j.gene.2014.09.056. Epub 2014 Sep 30.

     

    Hardware complications related to the surgical fixation of slipped capital femoral epiphyses. Massa E, Silk Z, Heidari N, Ramachandran M. J Long Term Eff Med Implants. 2014;24(2-3):163-71.

     

    Tibial eminence fractures in the paediatric population: a systematic review. Coyle C, Jagernauth S, Ramachandran M. J Child Orthop. 2014 Mar;8(2):149-59. doi: 10.1007/s11832-014-0571-6. Epub 2014 Mar 2.


    Developing an electronic teaching and training portfolio. Aresti N, Ramachandran M. Curr Rev Musculoskelet Med. 2014 Jun;7(2):172-6. doi: 10.1007/s12178-014-9204-4.

     

    Reverse Ponseti-type treatment for children with congenital vertical talus: comparison between idiopathic and teratological patients. Wright J, Coggings D, Maizen C, Ramachandran M. Bone Joint J. 2014 Feb;96-B(2):274-8.

    doi: 10.1302/0301-620X.96B2.32992.

     

    Acute haematogenous osteomyelitis in children. Yeo A, Ramachandran M. BMJ. 2014 Jan 20;348:g66. doi: 10.1136/bmj.g66. Review. Erratum in: BMJ. 2014;348:1326.

     

    Prevalence of developmental dysplasia of the hip in children with clubfoot. Chou DTs, Ramachandran M. J Child Orthop. 2013 Oct;7(4):263-7. doi: 10.1007/s11832-013-0523-6. Epub 2013 Aug 30.

     

    Current concepts in the treatment of adolescent femoroacetabular impingement. Ramachandran M, Azegami S, Hosalkar HS. J Child Orthop. 2013 Mar;7(2):79-90. doi: 10.1007/s11832-012-0473-4. Epub 2013 Jan 11. Review.

     

    The Pavlik method: a systematic review of current concepts. Tibrewal S, Gulati V, Ramachandran M. J Pediatr Orthop B. 2013 Nov;22(6):516-20. doi:10.1097/BPB.0b013e328365760e. Review.

     

    Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model. Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ, Chowdhury TT. Arthritis Res Ther. 2013 Jul 24;15(4):R76. doi: 10.1186/ar4253.

     

    Management of developmental dysplasia of the hip in young adults: current concepts. Kosuge D, Yamada N, Azegami S, Achan P, Ramachandran M.Bone Joint J. 2013 Jun;95-B(6):732-7. doi: 10.1302/0301-620X.95B6.31286. Review.

     

    Surgical treatment of femoroacetabular impingement in patients with slipped capital femoral epiphysis: A review of current surgical techniques. Azegami S, Kosuge D, Ramachandran M. Bone Joint J. 2013 Apr;95-B(4):445-51. doi: 10.1302/0301-620X.95B4.30245. Review.

     

    Longitudinal study of vitamin D metabolites after long bone fracture. Briggs AD, Kuan V, Greiller CL, Maclaughlin BD, Ramachandran M, Harris T, Timms PM, Venton TR, Vieth R, Norman AW, Griffiths CJ, Martineau AR. J Bone Miner Res. 2013 Jun;28(6):1301-7. doi: 10.1002/jbmr.1855.

    Livio Di Mascio

    Consultant Orthopaedic Surgeon

    Lead of Upper Limb Orthopaedic Surgery

    A review of wrist arthroscopy. Moore N, Filipek A, Di Mascio L. Orthop Trauma. Nov 2015 in press.

     

    Surgical Repair of Posterolateral Rotatory Instability of the Elbow Using Surgilig/ Lockdown: A Novel Surgical Technique. Williams D, Martin G, Di Mascio L. Tech Should Surg 2014;15: 87–91

     

    Classification and management of acute wounds and open fractures. Lee N, Di Mascio L. Surgery 29 (2014), pp134-138.

     

    Heiss-Dunlop W, Couzens GB, Peters SE, Gadd K, Di Mascio L, Ross M. Comparison of plain x-rays and computed tomography for assessing distal radioulnar joint inclination. J Hand Surg Am. 2014 Dec;39(12):2417-23.

     

    Ross M, Di Mascio L, Peters S, Cockfield A, Taylor F, Couzens G. Defining residual radial translation of distal radius fractures: a potential cause of distal radioulnar joint instability. J Wrist Surg. 2014 Feb;3(1):22-9.

     

    Zarattini G, Galli S, Marchese M, Di Mascio L, Pazzaglia UE. The surgical treatment of isolated mason type 2 fractures of the radial head in adults:comparison between radial head resection and open reduction and internal fixation. J Orthop Trauma. 2012 Apr;26(4):229-35.

     

    Pazzaglia UE, Congiu T, Franzetti E, Marchese M, Spagnuolo F, Di Mascio L, Zarattini G. A model of osteoblast-osteocyte kinetics in the development of secondary osteons in rabbits. J Anat. 2012 Apr;220(4):372-83.

    Paul Lee

    Consultant Orthopaedic Surgeon

    Antibiotic Treatment and Timing of Reimplantation - International Consensus on periprosthetic infection

    Restrepo C, Schmitt S, Backstein D, Alexander BT, Babic M, Brause BD, Esterhai JL, Good RP, Jørgensen PH, Lee PTH; et al. Journal of Orthopaedic Research. 2014 Jan; 32, Suppl 1:136-40 Journal of Arthroplasty.  2014 Feb; 29, Suppl 2:104–107

     

    Reconstruction of massive uncontained acetabular defects using allograft with cage or ring reinforcement: an assessment of the graft’s ability to restore bone stock and its impact on the outcome of re-revision

    Abolghasemian M, Sadeghi Naini M, Tangsataporn S, Lee P, Backstein D, Safir O, Kuzyk P, Gross AE. Journal of Bone and Joint Surgery. 2014 Mar 1; 96B(3): 319-24

     

    Trans-patella retrograde femoral nail, a novel surgical technique

    Jagernauth S, Martin G, Picardo NE, Lee PTH, Lee JKL Current Orthopaedic Practice. 2014 May/Jun; 25 (3): 284-287

     

    Distal Femoral Fresh Osteochondral Allografts: Follow-up at a Mean of 22 Years

    Raz G, Safir O, Backstein D, Lee P, Gross A. Journal of Bone and Joint Surgery. 2014 Jul 2;96(13):1101-1107

     

    Mid-to-long term results of revision hip arthroplasty in patients 50 years or younger

    Lee PTH, Lakstein D, Lozano B, Safir O, Backstein D, Gross AE Bone and Joint Journal. 2014 Aug; 96-B(8):1047-1051

  • Profiles

    Meet our team!

    Manoj Ramachandran

    Director of Orthopaedic Research

    Manoj is a Consultant Orthopaedic and Trauma Surgeon in paediatric and young adult orthopaedics and trauma at Barts Health, based at The Royal London and Barts and The London Children’s Hospitals. He is the Lead for Paediatric Orthopaedics and the Director of Informatics and Innovation for Surgery and Cancer. His clinical interests are in paediatric orthopaedics and trauma, especially of the lower limb, and the young adult hip and knee (including arthroscopy of the hip and knee, preservation and sports injuries). Manoj has built international research collaborations globally and is an Honorary Reader and Director of Clinical Strategy and Musculoskeletal Translational Research at the Institute of Bioengineering at QMUL.

    Jamila Kassam

    Lead Research Physiotherapist

    Jamila qualified as a physiotherapist from UWE in Bristol before starting work as a physiotherapist at Charing Cross Hospital. Having completed a variety of rotations as a junior and senior physiotherapist, Jamila was awarded a scholarship by the Medical Research Council to complete a Research Master’s Degree at Imperial College London. Jamila joined the Orthopaedic Department in April 2013 in a new role as a research physiotherapist, working with Manoj to initially build a research infrastructure, and is now delivering and developing research studies.

    Catherine Hilton

    Research Physiotherapist

    Catherine qualified as a physiotherapist at the University of Brighton and has worked in NHS Trusts across London since 2007. Catherine was successful in obtaining a fellowship with the NIHR and completed a Clinical Research Master's Degree at King's College London.
    Having recently joined the team in May 2015, she is supporting NIHR portfolio studies and working with the Manoj and Jamila to expand our existing research activity.

    Paul Lee

    Consultant Orthopaedic Surgeon

    Paul is a consultant orthopaedic surgeon at Barts Health NHS Trust. His main clinical interests are in hip and knee arthroplasty reconstruction (primary and revision), young adult hip preservation surgery (peri-acetabular osteotomy, arthroscopy), and the surgical management of peri-prosthetic joint infection. His research interests and peer review publications are focused in these areas. He had previously published in basic sciences involving metal ions associated with metal-on-metal bearing, lubricant surface tension properties associated with bearing surfaces and the effects of inert synthetic lubrication, growth factors and synthetic bone graft in animal models.

  • Blog

    What's coming up and what's up-and-coming

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